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Welcome to EMBO reports
The EMBO reports special issue on The Future Of Our Species is available online. Global climate change, space exploration, disease, genetic enhancement, evolution and extended lifespans are just some of the topics addressed by the authors. Humankind is facing both its greatest challenges and its biggest opportunities; how we deal with each may well determine the future of our species.
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Towards preventive medicine 
The future of agriculture
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Science and Society in full... |
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The role of splicing factors in cancer
Functions of poly(ADP-ribosyl)ation
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Reviews in full... |
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Mitochondrial import: Hot13 aids in Mia40 oxidation
The Herrmann lab provides insight into the mitochondrial Mia40-Erv1 disulfide relay system by investigating the role of a third component, Hot13, a conserved zinc-binding protein. They show that Hot13, by keeping the import receptor Mia40 in a zinc-free state, facilitates the oxidation of Mia40 by the sulfhydryl oxidase Erv1. In doing this, Hot13 plays a critical role for mitochondrial protein import in the presence of zinc.
Evolutionary basis for Stat DNA-binding preferences
The report by Rivas et al, shows that the diversity of STAT binding sites is not a recent evolutionary adaptation of the STAT family of transcription factors. In contrast to the current view, which is that diverse STAT binding sites evolved following the radiation of the seven vertebrate STAT proteins, Rivas et al, show that the single Drosophila STAT92E is able to bind to and activate the expression of target genes via different DNA binding sites. This variation in binding sites is an efficient way to modulate transcription levels.
Daughterless negatively regulates proneural genes
The report by Lim and colleagues highlights a new function for the Class I bHLH transcription factor Daughterless in the neural differentiation in the Drosophila eye. The authors show that Daughterless not only promotes retinal neurogenesis by activating certain Class II bHLH transcription factors, but also represses it by inhibiting the proneural gene atonal (ato). This dual function of Daughterless has important consequences for the neural patterning in the eye.
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| Scientific Reports in full... |
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 Science and Society Special Issue
Volume 9, July 2008
The future of our species
Click here to view Special Issue
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